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Comparison of the primate alphaherpesviruses - I. Characterization of two Herpesviruses from spider monkeys and squirrel monkeys and viral polypeptides synthesized in infected cells

Archives of Virology, ISSN: 0304-8608, Vol: 91, Issue: 1-2, Page: 117-133
1986
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Biological and biochemical properties of two neurotropic herpesviruses of New World monkeys-Herpesvirus saimiri type 1 (HVS-1) and Herpesvirus ateles type 1 (HVA-1)-were examined and compared. HVS-1 and HVA-1 both exhibited a time course of replication similar to another primate herpesvirus, SA 8. Both viruses grew rapidly and high titers of infectious virus were readily produced. HVS-1 and HVA-1 were also able to replicate efficiently in cell lines derived from a number of primate and non-primate species. Analysis of proteins synthesized in infected cells revealed the presence of over 30 virus-specific proteins ranging from <30,000 to over 200,000 daltons apparent molecular weight. Both viruses specified synthesis of a major capsid polypeptide of 148,000 daltons. Pulse labeling of cells during infection demonstrated temporal differences in the kinetics of synthesis of individual viral proteins and post-translational modification of a number of viral polypeptides. Glycosylated polypeptides synthesized in HVS-1 and HVA-1 infected cells were identified which ranged from approximately 49,000 to 120,000 daltons. Structural polypeptides of HVA-1 and HVS-1 virions were identified by SDS-PAGE analysis of purified virions. Taken together with clinical data on the diseases caused by these viruses, these studies indicate that HVS-1 and HVA-1 appear similar in many respects to both the human herpes simplex viruses and alphaherpesviruses of other primates. © 1986 Springer-Verlag.

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