Gastrointestinal damage induced by platelet-activating factor - Inhibition by the corticoid, dexamethasone
Digestive Diseases and Sciences, ISSN: 0163-2116, Vol: 33, Issue: 2, Page: 225-232
1988
- 11Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- CrossRef11
- 11
- Captures4
- Readers4
Article Description
Intravenous infusion of platelet-activating factor (PAF-acether) induces extensive vasocongestion and damage in the stomach and small intestine of the rat. The effect of pretreatment with the corticoid dexamethasone (2 mg/kg) on such gastrointestinal damage in the rat has now been investigated, using macroscopic observation and the release of acid phosphatase, as an enzyme marker of cell disruption. Administration of PAF-acether (100 ng/kg/min intravenously, for 10 min) induced focal, intense hyperemia and hemorrhage in all the regions of the gastrointestinal tract, with the exception of the distal colon. This damage was associated with an increase in the release of acid phosphatase into the lumen of the stomach, duodenum, jejunum, and ileum following incubation in vitro. Pretreatment with dexamethasone reduced the macroscopically apparent gastrointestinal damage following PAF-acether administration and abolished the intraluminal release of acid phosphatase. Dexamethasone also significantly suppressed the hemoconcentration, as determined by changes in platelet and erythrocyte count and hematocrit, 30 min after PAF-acether infusion. Thus, as in endotoxin shock, this glucocorticoid can reduce the gastrointestinal damage associated with PAF-acether administration. © 1988 Plenum Publishing Corporation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023867590&origin=inward; http://dx.doi.org/10.1007/bf01535737; http://www.ncbi.nlm.nih.gov/pubmed/3338370; http://link.springer.com/10.1007/BF01535737; https://dx.doi.org/10.1007/bf01535737; https://link.springer.com/article/10.1007/BF01535737; http://www.springerlink.com/index/10.1007/BF01535737; http://www.springerlink.com/index/pdf/10.1007/BF01535737
Springer Science and Business Media LLC
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