PlumX Metrics
Embed PlumX Metrics

Immunohistochemical localization of xenogeneic antibodies against Ia lymphocytes on B cells and reticular cells

Immunogenetics, ISSN: 0093-7711, Vol: 6, Issue: 1, Page: 367-377
1978
  • 37
    Citations
  • 0
    Usage
  • 1
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    37
    • Citation Indexes
      37
  • Captures
    1

Article Description

Rabbit antiserum against B10.AQR mouse spleen and lymph node cells (RAQR), after appropriate absorption, reacted with Ia-positive spleen and lymph node cells in cytotoxic and complement-fixing indicator systems. It reacted neither with Ia-positive thymocytes nor Ia-negative thymocytes, spleen, and lymph node cells. Cryostat sections of tissue from Ia-positive and Ia-negative mice were incubated with RAQR and either rabbit anti-mouse Ig or rabbit anti-T cell globulin. With the unlabeled antibody enzyme method, RAQR-stained lymphocytes were concentrated in the B-cell regions of spleen and lymph nodes of Ia-positive CBA mice. The tissues of mice bearing I-region haplotypes different from k were negative. Reticular cells of the T cell-supporting network were also positive in Ia mice, but liver, gall bladder, and testicular cells were not. Macrophages of both Ia-positive and -negative mice were stained by RAQR and also by heat-aggregated, peroxidase-labeled Ig. Ia-positive reticular cells survived 900 R total body irradiation and persisted after grafting with Ia-negative bone marrow. The reticular cells were also seen in a thymus which was depleted of cortisone-sensitive lymphocytes. © 1978 Springer-Verlag New York Inc.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know