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D-Glucose does not catabolite repress a transketolase-deficient D-ribose-producing Bacillus subtilis mutant strain

Journal of Industrial Microbiology, ISSN: 0169-4146, Vol: 17, Issue: 2, Page: 104-109
1996
  • 17
    Citations
  • 0
    Usage
  • 6
    Captures
  • 0
    Mentions
  • 0
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Metrics Details

  • Citations
    17
    • Citation Indexes
      17
  • Captures
    6

Article Description

When Bacillus subtilis strain ATCC 21951, a transketolase-deficient D-ribose-producing mutant, was grown on D-glucose plus a second substrate which is metabolized via the oxidative pentose phosphate cycle (D-gluconic acid, D-xylose, L-arabinose or D-xylitol), D-glucose did not catabolite repress metabolism of the second carbon source. The D-ribose yield obtained with the simultaneously converted carbon substrates, significantly exceeded that when only D-glucose was used. In addition, the concentration of glycolytic by-products and the fermentation time significantly decreased. Based on these findings, a fermentation process was developed with B. subtilis strain ATCC 21951 in which D-glucose (100 g L) and D-gluconic acid (50 g L) were converted into 45 g L of D-ribose and 7.5 g L of acetoin, A second process, based on D-glucose and D-xylose (100 g L each), yielded 60 g L of D-ribose and 4 g L of acetoin plus 2,3-butanediol. Both mixed carbon source fermentations provide excellent alternatives to the less efficient D-glucose-based processes used so far.

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