Influence of dehydrocholate sodium on the biliary reabsorption of sulfobromophthalein sodium from the rat biliary tree after retrograde intrabiliary injection
Klinische Wochenschrift, ISSN: 0023-2173, Vol: 54, Issue: 16, Page: 789-791
1976
- 3Citations
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef3
Article Description
Biliary re-excretion of sulfobromophthalein sodium (BSP) (1.2 μmol/rat) after retrograde intrabiliary injection is markedly inhibited by dehydrocholate sodium (Decholin) given intravenously as a constant infusion (3.1 μmol/min/kg body weight) or as a bolus injection (24.8 μmol/rat) to rats. Most interestingly Decholin demonstrates the same inhibitory effects on the biliary re-excretion of BSP when it is administered by retrograde intrabiliary injection (24.8 μmol/rat) together with the dye. In contrast to the inhibition of biliary re-excretion of BSP its biliary reabsorption from the biliary tract seems to be rather increased: about 80-85% of 1.2 μmol BSP are reabsorbed in all sets of experiments with Decholin in comparison to about 65% to the control group. Combined with histological data it is suggested that reabsorption of BSP after retrograde intrabiliary injection occurs at the ductular site whereas re-excretion takes place at the cannalicular membrane of the hepatocyte. © 1976 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0017062297&origin=inward; http://dx.doi.org/10.1007/bf01614296; http://www.ncbi.nlm.nih.gov/pubmed/957600; http://link.springer.com/10.1007/BF01614296; http://www.springerlink.com/index/pdf/10.1007/BF01614296; https://dx.doi.org/10.1007/bf01614296; https://link.springer.com/article/10.1007/BF01614296; http://www.springerlink.com/index/10.1007/BF01614296
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