Competitive blocking of epithelial sodium channels by organic cations: The relationship between macroscopic and microscopic inhibition constants
The Journal of Membrane Biology, ISSN: 0022-2631, Vol: 76, Issue: 3, Page: 235-251
1983
- 36Citations
- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations36
- Citation Indexes36
- CrossRef36
- 31
- Captures1
- Readers1
Article Description
Fluctuation analysis of Na current passing the apical membrane in the skin of Rana ridibunda was used to study the kinetics of Na-channel blocking by several organic cations present in the outer solution together with 60 mm Na. The ratios of the apparent off-rate and on-rate constants (the microscopic inhibition constants) thus obtained for triamterene, triaminopyrimidine (TAP), 5,6-diCl-amiloride, 5H-amiloride and amiloride itself are found to be in the mean about sevenfold smaller than the corresponding inhibition constants obtained from macroscopic dose-response curves. The apparent discrepancy is explicable by competition of the organic blocker with the channel block by Na ions (the self-inhibition effect). The type of interaction between extrinsic blockage and self-inhibition may be purely competitive or mixed. However, in case of mixed inhibition the competitive component must dominate the noncompetitive component by at least seven to one. © 1983 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0021012702&origin=inward; http://dx.doi.org/10.1007/bf01870366; http://www.ncbi.nlm.nih.gov/pubmed/6100864; http://link.springer.com/10.1007/BF01870366; http://www.springerlink.com/index/pdf/10.1007/BF01870366; https://dx.doi.org/10.1007/bf01870366; https://link.springer.com/article/10.1007/BF01870366; http://www.springerlink.com/index/10.1007/BF01870366
Springer Nature
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