Long-term low-dose cyclosporin A in steroid dependent nephrotic syndrome of childhood
European Journal of Pediatrics, ISSN: 0340-6199, Vol: 151, Issue: 10, Page: 775-778
1992
- 34Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations34
- Citation Indexes33
- 33
- CrossRef15
- Clinical Citations1
- PubMed Guidelines1
- Captures12
- Readers12
- 12
Article Description
Therapy of steroid-dependent idiopathic nephrotic syndrome is often unsatisfactory. Since 1986 we have treated nine children (six male and three female), aged 3-16 years, with cyclosporin A (CsA) during 2.0-5.2 (median 3.1) years. All had minimal change disease on renal biopsy and had previously received cyclophosphamide. Mean daily dosage of CsA was 4.1 mg/kg (range 2.7-5.8) and mean whole blood trough level was 220ng/ml (range 141-271). The relapse rate decreased from 3.4/patient year before CsA to 0.55 on CsA. Discontinuation of CsA or reduction below 2 mg/kg daily was always followed by a relapse. The overall relapse rate, including the period with very low-dose CsA, was 0.95/patient year. Four patients required additional low-dose alternate-day prednisone. Repeat renal biopsy showed minimal change disease in eight patients and focal segmental glomerulosclerosis in one; CsA-toxicity was mild in two and moderate in one. The latter was the only patient with slightly reduced glomerular filtration rate. Two boys with delayed puberty spontaneously matured and reached expected final height. We conclude that long-term low-dose CsA is very effective and steroid-sparing. Its use is justified in selected patients, particularly in those with numerous relapses and in male patients before and during puberty, as long as renal function and CsA-toxicity are carefully monitored. © 1992 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026700171&origin=inward; http://dx.doi.org/10.1007/bf01959089; http://www.ncbi.nlm.nih.gov/pubmed/1425802; http://link.springer.com/10.1007/BF01959089; http://www.springerlink.com/index/pdf/10.1007/BF01959089; http://www.springerlink.com/index/10.1007/BF01959089; https://dx.doi.org/10.1007/bf01959089; https://link.springer.com/article/10.1007/BF01959089
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