Toxicological studies with primary cultures of chick embryo cells: DNA fragmentation under the influence of DNase I-inhibitors
Archives of Toxicology, ISSN: 0340-5761, Vol: 67, Issue: 5, Page: 318-324
1993
- 9Citations
- 2Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Chicken embryo brain and liver cells in vitro exhibited spontaneous DNA fragmentation as determined by viscometry of alkaline cell lysates. Ca and Mg enhanced, while Zn, the Ca chelator ethylenglycolbis(β-aminoethyl-ether)-N, N, N′-tetraacetic acid (EGTA), spermine and - to a lesser extent - spermidine and Hoechst 33258 inhibited spontaneous DNA fragmentation. Under the same conditions chromatin condensation, as assessed by nucleoid sedimentation, increased. Exposure of chicken embryo cells to various genotoxic agents, i.e. doxorubicin, bleomycin, methyl methanesulfonate, thiyl radicals, HO, UV light, and X-rays, increased DNA fragmentation in a dose dependent manner. Zn or EGTA diminished DNA fragmentation in cells exposed to bleomycin, thiyl radicals, HO and UV light. An apparent sensitisation to X-irradiation has been observed in Zn or EGTA-pretreated cells. It is suggested by the present investigations that, with agent specific peculiarities, apoptotic phenomena are implicated when nucleotoxicity is assessed in chicken embryo cells by physico-chemical short-term tests in vitro. © 1993 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027287851&origin=inward; http://dx.doi.org/10.1007/bf01973702; http://www.ncbi.nlm.nih.gov/pubmed/8368942; http://link.springer.com/10.1007/BF01973702; http://www.springerlink.com/index/pdf/10.1007/BF01973702; https://dx.doi.org/10.1007/bf01973702; https://link.springer.com/article/10.1007/BF01973702; http://www.springerlink.com/index/10.1007/BF01973702
Springer Nature
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know