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The eye lens crystallins: Ambiguity as evolutionary strategy

Journal of Molecular Evolution, ISSN: 0022-2844, Vol: 24, Issue: 1-2, Page: 121-129
1986
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Article Description

Comparative studies of the different families of lens-specific proteins of the vertebrates, the crystallins, and their genes reveal several interesting evolutionary features. The origin of α-crystallin can be traced back to the small heat shock proteins, while the superfamily of βγ-crystallins shows structural similarities with a bacterial spore coat protein. The crystallins display a great diversity within and between species, as well as during development. Ambiguous transcription, mRNA-processing, and translation contribute to this diversity of the crystallins and their expression. These mechanisms include the occurrence of atypical poly-A addition signals, alternative splicing, and the use of two initiation codons on a single mRNA. © 1986 Springer-Verlag New York Inc.

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