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Administration of leu-enkephalin impairs the acquisition of preference for ethanol

Psychopharmacology, ISSN: 0033-3158, Vol: 100, Issue: 3, Page: 350-354
1990
  • 8
    Citations
  • 0
    Usage
  • 10
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    8
    • Citation Indexes
      8
  • Captures
    10

Article Description

The effects of subcutaneous administration of leuenkephalin (LEU-E) (10, 100 and 300 μg/kg) and LEU-E (100 μg/kg) plus naloxone (2.5 mg/kg) on ethanol preference and fluid intake have been investigated in rats. Under our procedural conditions, rats develop ethanol preference through forced ethanol drinking (conditioning session). Preconditioning administration of LEU-E induced a reduction of later ethanol preference. Post-conditioning administration of LEU-E (10 and 100 μg/kg) also attenuated the development of ethanol preference. NX antagonized the effects of LEU-E on ethanol preference and fluid consumption in the two experimental procedures used, indicating an involvement of opioid receptors in the LEU-E-induced impairment of the acquisition of ethanol preference. © 1990 Springer-Verlag.

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