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Acute immobilization stress reduces (±DOI)-induced 5-HT receptor-mediated head shakes in rats

Psychopharmacology, ISSN: 0033-3158, Vol: 119, Issue: 1, Page: 9-14
1995
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Acute immobilization stress induced by taping four limbs, applying tail pinch stress and electric foot shock stress immediately reduced the frequency of head shakes induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ((±)DOI), a 5-HT agonist in rats. Immobilization stress due to the use of cylinder restraint and forced swimming did not affect 5-HT-mediated behavior. Acute immobilization stress did not affect [H]ketanserin binding to the 5HT receptor in the prefrontal cortex and hippocampus. Presynaptic serotonergic lesions with 5,7-dihydroxytryptamine (5,7-DHT) did not affect the reduction in 5-HT-mediated behavior after acute immobilization stress. The decreases in head shake frequency after acute immobilization stress by taping were attenuated by pretreatment with diazepam (2.5 mg/kg IP): This attenuation was reversed by pretreatment with flumazenil (10 mg/kg IP). The reduction in (±)DOI- induced 5-HT-mediated behavior caused by stress may be related to a change in agonist affinity to the receptor or changes in other neurotransmitter systems or the effect of PI turnover. © 1995 Springer-Verlag.

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