Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles
Journal of Biomedical Science, ISSN: 1021-7770, Vol: 10, Issue: 6 II, Page: 774-781
2003
- 22Citations
- 19Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef17
- Captures19
- Readers19
- 17
- Mentions1
- References1
- Wikipedia1
Article Description
We have previously shown that the membrane-associated form of the GABA-synthesizing enzyme, glutamate (decarboxylase 65 (GAD), is activated by synaptic vesicle proton gradient-mediated protein phosphorylation. We now report that the rate-limiting enzyme in dopamine (DA) biosynthesis, tyrosine hydroxylase (TH), is regulated similarly to GAD. The membrane-associated form of TH (MTH) was activated by conditions favoring protein phosphorylation (e.g. ATP) and was inhibited by phosphatase (e.g. calf intestine phosphatase). Furthermore, the ATP-mediated activation of MTH was abolished by conditions that disrupted the proton gradient of synaptic vesicles, e.g. the presence of carbonyl cyanide m-chorophenylhydrazone, gramicidin, or the V-type ATPase inhibitor (bafilomycin), but not the P-type ATPase inhibitor (vanadate). Moreover, DA newly synthesized from tyrosine by MTH and membrane-associated aromatic amino acid decarboxylase was taken up preferentially rather than pre-existing DA. Therefore, the previously proposed model showing close coupling between GABA synthesis and GABA packaging into synaptic vesicles by vesicular GABA transporters is also applicable to the DA system. Hence, it is concluded that there is a general coupling mechanism between neurotransmitter synthesis and packaging of transmitter into synaptic vesicles. Copyright © 2003 National Science Council, ROC and S. Karger AG, Basel.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0346787883&origin=inward; http://dx.doi.org/10.1159/000073965; http://www.ncbi.nlm.nih.gov/pubmed/14631117; http://www.karger.com/doi/10.1159/000073965; http://link.springer.com/10.1007/BF02256330; http://dx.doi.org/10.1007/bf02256330; https://dx.doi.org/10.1159/000073965; https://link.springer.com/article/10.1007/BF02256330; https://link.springer.com/article/10.1007%2FBF02256330; http://www.springerlink.com/index/10.1007/BF02256330; http://www.springerlink.com/index/pdf/10.1007/BF02256330; http://www.karger.com/Article/Abstract/73965; http://www.karger.com/Article/FullText/73965; http://www.karger.com/Article/Pdf/73965; https://link.springer.com/content/pdf/10.1007%2FBF02256330.pdf; http://www.karger.com/OpenUrl/Index/000073965; http://link.springer.com/article/10.1007%2FBF02256330; https://link.springer.com/content/pdf/10.1007/BF02256330.pdf
Springer Nature America, Inc
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