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A method for quantitative determination of methyl methacrylate monomer in bone surgery by headspace analysis of blood

Chromatographia, ISSN: 0009-5893, Vol: 7, Issue: 2, Page: 55-58
1974
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Metrics Details

  • Citations
    6
    • Citation Indexes
      6

Article Description

A gas chromatographic method is described which permits the quantitative determination of monomeric methyl methacrylate in human blood after bone cement implantations. The headspace method was applied in order to keep the proportion of blood components which upset the determination as low as possible. The evaluation was from calibration curves with n-butylacetate as an internal standard. In case of hip-joint operations the MMA concentrations in the blood of the patient have been measured in a sample taken immediately after the implantation of the bone cement. From this process a methodical basis results for the elucidation of the connection between serious cardiovascular complications and the uptake of methyl methacrylate monomer by the circulatory system. © 1974 Friedr. Vieweg & Sohn, Verlagschesellschaft mbH.

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