Kinetics of tumour necrosis factor-alpha, soluble tumour necrosis factor receptors, interleukin 1-beta and its receptor antagonist during serious infections
European Journal of Clinical Microbiology & Infectious Diseases, ISSN: 0934-9723, Vol: 13, Issue: 1 Supplement, Page: S12-6
1994
- 30Citations
- 22Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations30
- Citation Indexes30
- 30
- CrossRef25
- Captures22
- Readers22
- 22
Review Description
Tumour necrosis factor-α (TNF) and interleukin-1β (IL-1β) are the central mediators in the genesis of sepsis. The proinflammatory effects of these cytokines are counteracted in vivo by natural inhibitors. Soluble TNF receptors (sTNFR) are shed upon inflammatory stimuli such as IL-1β and TNF itself. Circulating TNF can be complexed by these receptors, thus preventing TNF from binding to effector cells. The binding of IL-1β to its receptor can be blocked by high concentrations of interleukin-1 receptor antagonist (IL-1Ra), which is produced and released upon nearly the same stimuli as IL-1β. This review presents some aspects of the kinetic behaviour of native sTNFR and of the production of native IL-1Ra during severe infections. It appears that in fulminant septicaemia, the plasma concentration of TNF is increased only transiently, during the very early stage of the infection. The concentration of sTNFR, in contrast, remains elevated much longer, probably due to a slower clearance. During the acute stage of severe infectious diseases, peripheral blood cells cannot be stimulated to produce IL-1β. The production of IL-1Ra, in contrast, is not affected. Thus, the kinetic behaviour and regulation of TNF and IL-1β, is different from that of their antiinflammatory counterparts. © 1994 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028025320&origin=inward; http://dx.doi.org/10.1007/bf02390680; http://www.ncbi.nlm.nih.gov/pubmed/7821299; http://link.springer.com/10.1007/BF02390680; http://www.springerlink.com/index/pdf/10.1007/BF02390680; http://www.springerlink.com/index/10.1007/BF02390680; https://dx.doi.org/10.1007/bf02390680; https://link.springer.com/article/10.1007/BF02390680
Springer Nature
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know