Inhibition of active bone resorption by copper
Calcified Tissue International, ISSN: 0171-967X, Vol: 33, Issue: 1, Page: 35-39
1981
- 49Citations
- 17Captures
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Metrics Details
- Citations49
- Citation Indexes49
- 49
- CrossRef38
- Captures17
- Readers17
- 17
Article Description
An investigation of the role of copper in bone metabolism was undertaken. Explanted calvaria from 6-day-old mice were grown for 48 h in medium with and without the addition of copper sulfate. Active resorption was found to be significantly inhibited in the presence of copper sulfate concentrations of 10M and above. Copper sulfate concentrations of 10M and above inhibited hydroxyproline, protein, and DNA synthesis. Lower concentrations were ineffective. The effect of 5 × 10M copper sulfate on resorption was reversible. Several other compounds were tested for similar effects and at 5 × 10M were found to inhibit bone resorption in the order: copper sulfate > brown gold chloride > sodium aurothiomalate > zinc sulfate > sodium sulfate. The copper sulfate effect was twice that of sodium aurothiomalate, and sodium sulfate was not significantly inhibitory. The results suggest that the high serum copper levels associated with rheumatoid arthritis may reflect the activity of a hypothetical control mechanism of bone resorption. In the diseased state this would act to restore the normal rate of bone resorption. © 1981 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019350423&origin=inward; http://dx.doi.org/10.1007/bf02409410; http://www.ncbi.nlm.nih.gov/pubmed/6780154; http://link.springer.com/10.1007/BF02409410; http://www.springerlink.com/index/pdf/10.1007/BF02409410; https://dx.doi.org/10.1007/bf02409410; https://link.springer.com/article/10.1007/BF02409410; http://www.springerlink.com/index/10.1007/BF02409410
Springer Science and Business Media LLC
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