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Parallel computation enables precise description of Ca 2+ distribution in nerve terminals

Bulletin of Mathematical Biology, ISSN: 0092-8240, Vol: 58, Issue: 6, Page: 1075-1097
1996
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Article Description

Parallel computation employing a domain decomposition method was used to calculate precisely without approximations the spatio-temporal distribution of Ca 2+ in nerve terminals. The results showed, contrary to expectations, that for equal admitted Ca 2+ currents at low (one channel open) and high (four channels open) depolarization, the average Ca 2+ concentration at the release area is higher at the low depolarization. These calculations provide additional support for the Ca 2+ -voltage hypothesis for neurotransmitter release.

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