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Macrophages release melanocyte dendrite extension factor in response to ultra-violet ray

In Vitro Cellular & Developmental Biology - Animal, ISSN: 1071-2690, Vol: 29, Issue: 5, Page: 419-426
1993
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Article Description

Mammalian melanocytes in epidermis extend their dendrites in response to UV ray in vivo in addition to proliferation and pigmentation. We found that cultured macrophages exert a factor in response to UV irradiation and that this factor induces the extension of dendrites of melanocyte. We designated this factor as dendrite extension factor (DEF) and characterized it as a protein. Our results indicate that the molecular weight of DEF is 30 000 ∼ 100 000 and that it is heat-labile. Macrophages release DEF through transcription and translation. DEF seems to be a novel factor that enhances melanogenesis by UV irradiation. © 1993 Tissue Culture Association.

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