Regulation of stress-induced transcriptional changes in the hypothalamic neurosecretory neurons
Journal of Molecular Neuroscience, ISSN: 0895-8696, Vol: 7, Issue: 2, Page: 125-133
1996
- 107Citations
- 37Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations107
- Citation Indexes107
- 107
- CrossRef82
- Captures37
- Readers37
- 37
Article Description
Transcriptional changes in corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) gene expression were studied by in situ hybridization histochemistry using cRNA probes directed against intronic sequences. Acute ether stress resulted in a rapid induction of CRF and a delayed activation of vasopressin heteronuclear (hn)RNA in the parvocellular neurosecretory neurons within the paraventricular nucleus (PVN) of the hypothalamus. To explore possible molecular mechanisms regulating stress-related neuropeptide expression in vivo, the time-courses of stress-induced activation of different transcription factor classes were compared to that of changes in neuropeptide transcription. The peak of CRF transcription was parallel to that of cAMP response-element binding protein (CREB) phosphorylation but preceded the induction of c-fos and NGFI-B mRNAs and Fos protein. In contrast, AVP expression occurred in step with immediate-early gene (IEG) responses, suggesting involvement of different mechanisms underlying stress-induced neuropeptide responses. The interference of glucocorticoid hormones with stress-induced neuropeptide and transcription-factor responses has also been revealed in rats acutely or chronically pretreated with glucocorticoids. Acute dexamethasone injection did not prevent neuropeptide and transcription factor responses to ether inhalation, whereas chronic corticosterone administration completely blocked IEG and neuropeptide induction in the stress-related neurosecretory neurons. Copyright © 1996 Humana Press Inc. All rights of any nature whatsoever reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030155495&origin=inward; http://dx.doi.org/10.1007/bf02736792; http://www.ncbi.nlm.nih.gov/pubmed/8873896; http://link.springer.com/10.1007/BF02736792; http://www.springerlink.com/index/pdf/10.1007/BF02736792; http://www.springerlink.com/index/10.1007/BF02736792; https://dx.doi.org/10.1007/bf02736792; https://link.springer.com/article/10.1007/BF02736792
Springer Nature
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