Blood flow and oxygenation status of human tumors: Clinical investigations
Strahlentherapie und Onkologie, ISSN: 0179-7158, Vol: 175, Issue: 1, Page: 1-9
1999
- 64Citations
- 3Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations64
- Citation Indexes63
- 63
- CrossRef38
- Patent Family Citations1
- 1
- Captures3
- Readers3
- Mentions1
- References1
- 1
Review Description
Purpose: There is a large body of evidence suggesting that blood flow and oxygenation of human tumors are important research topics which may explain, in particular, resistance to radiation and to many antineoplastic drugs, which can limit the curability of solid tumors by radiotherapy and chemotherapy. Materials and Methods: This manuscript reviews the clinical investigations which have been performed regarding blood flow and oxygenation status of human tumors in radiation oncology. Results: The possible uses and limitations of the prognostic significance and the changes under therapy measuring blood flow and oxygenation in human tumors were discussed. In addition, several approaches were summarized, which can improve the microvascular O availability and perfusion-limited O delivery. Conclusion: The clinical data concerning the prognostic significance of blood flow, vascular function and oxygenation of human tumors are relevant for patient selection in clinical oncology. Strategies to improve traditional cancer therapy by modulation of the oxygenation status remain quite promising but more critical research and sophisticated clinical studies are necessary before its true potential is known.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032905752&origin=inward; http://dx.doi.org/10.1007/bf02743452; http://www.ncbi.nlm.nih.gov/pubmed/9951511; http://link.springer.com/10.1007/BF02743452; http://link.springer.com/content/pdf/10.1007/BF02743452; http://link.springer.com/content/pdf/10.1007/BF02743452.pdf; http://link.springer.com/article/10.1007/BF02743452/fulltext.html; https://dx.doi.org/10.1007/bf02743452; https://link.springer.com/article/10.1007/BF02743452
Springer Science and Business Media LLC
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