Dietary folate affects the response of rats to nickel deprivation
Biological Trace Element Research, ISSN: 0163-4984, Vol: 52, Issue: 1, Page: 23-35
1996
- 31Citations
- 13Captures
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Article Description
Because vitamin B and Ni are known to interact and because of the similar metabolic roles of vitamin B and folate, an experiment was performed to determine the effect of dietary folate on Ni deprivation in rats. A 2 x 2 factorially arranged experiment used groups of nine weanling Sprague-Dawley rats. Dietary variables were Ni, as NiCl·6HO, 0 or 1 μg/g; and folic acid, 0 or 2 mg/kg. The basal diet, based on skim milk, contained less than 20 ng Ni/g. After 54 d, an interaction between dietary Ni and folate affected several variables including erythrocyte folate, plasma amino acids, and femur trace elements. For example, folate deprivation decreased erythrocyte folate; folate supplementation to the Ni-supplemented rats caused a larger increase in erythrocyte folate concentration than did folate supplementation to the Ni-deprived rats. Also, dietary Ni affected several plasma amino acids important in one-carbon metabolism (e.g., Ni deprivation increased the plasma concentrations of glycine and serine). This study shows that dietary Ni, folate, and their interaction can affect variables associated with one-carbon metabolism. This study does not show a specific site of action of Ni but it indicates that Ni may be important in processes related to the vitamin B-dependent pathway in methionine metabolism, possibly one-carbon metabolism.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029885834&origin=inward; http://dx.doi.org/10.1007/bf02784087; http://www.ncbi.nlm.nih.gov/pubmed/8860663; http://link.springer.com/10.1007/BF02784087; http://www.springerlink.com/index/pdf/10.1007/BF02784087; http://www.springerlink.com/index/10.1007/BF02784087; https://dx.doi.org/10.1007/bf02784087; https://link.springer.com/article/10.1007/BF02784087
Springer Science and Business Media LLC
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