Interleukin-1α-induced changes in chromium-51 absorption, tissue retention, and urinary excretion in rats
Biological Trace Element Research, ISSN: 0163-4984, Vol: 68, Issue: 2, Page: 175-180
1999
- 5Citations
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef3
Article Description
The effects of interleukin-1 alpha (IL-1α) on chromium-51 absorption, tissue retention, and urinary excretion were studied in adult male Sprague- Dawley rats. Ten rats were deprived of food for 12 h, injected intraperitoneally with mouse recombinant IL-1α (1 μg/kg of body weight in phosphate-buffered saline [PBS]) or control (0.1% bovine serum albumin [BSA] in PBS). Two hours after dosing with the IL-1α, rats were fed 50 μL (200 μCi, 0.36 μg Cr) of CrCl by micropipet. Blood was collected from the tail at 0.25, 0.5, 1, 2, and 4 h. Six hours after dosing with CrCl, rats were exsanguinated and blood and tissues were sampled. The IL-1α significantly decreased chromium-51 in blood, urine, and some tissues compared to the control. The decreased absorption, retention, and urinary excretion of chromium-51 from CrCl in this study may be due to IL-1α- mediated increases in the production of prostaglandins and/or decreased production of gastric acid.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032588246&origin=inward; http://dx.doi.org/10.1007/bf02784405; http://www.ncbi.nlm.nih.gov/pubmed/10327027; http://link.springer.com/10.1007/BF02784405; http://www.springerlink.com/index/pdf/10.1007/BF02784405; http://www.springerlink.com/index/10.1007/BF02784405; https://dx.doi.org/10.1007/bf02784405; https://link.springer.com/article/10.1007/BF02784405
Springer Science and Business Media LLC
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