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Intermediary metabolite profiles during euglycemic glucose-insulin clamp: Effects of ethanol

La Ricerca in Clinica e in Laboratorio, ISSN: 0390-5748, Vol: 16, Issue: 3, Page: 471-479
1986
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Article Description

We evaluated the effects of different doses of i.v. alcohol on tissue insulin sensitivity, by means of insulin-glucose clamp technique, in 10 young healthy men. The most important intermediary metabolites were assayed. Insulin-dependent glucose disposal was impaired at different levels of alcoholemia, probably through an impairment of the glycolytic pathway. Exogenous insulin administration does not restore the more reduced redox state caused by alcohol oxidation. Alcohol does not interfere with the antiketogenic and antilipolytic insulin effects. © 1986 Casa Editrice «Il Ponte».

Bibliographic Details

Elena Duner; Angelo Avogaro; Maria Cristina Marescotti; Romano Nosadini; Antonio Riccio; Roberto Trevisan; Antonio Tiengo

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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