Modulation of KB and A431 cell adhesion by epidermal growth inhibitory pentapeptide
Virchows Archiv B Cell Pathology Including Molecular Pathology, ISSN: 0042-6431, Vol: 62, Issue: 1, Page: 353-356
1992
- 2Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
A pentapaptide, pyroGlu-Glu-Asp-Ser-GlyOH (EPP), isolated from mouse epidermis, inhibits mitoses and enhances differentiation in primary cultures and in transformed mouse epidermal cells in vitro (Elgjo et al. 1986b). The present work demonstrates that EPP also modulates the adhesiveness of two human tumour cell lines (KB and A431) of epidermal origin to uncoated plastic and to plastic coated with fibrinogen or collagen type 1. The adhesion modulatory effect of EPP was observed over a broad range of concentrations (10-10 M), and depended on the substrate the cells were growing on. Thus, when cells were seeded on plastic or collagen, the attachment to the substrate was suppressed at the highest concentrations of EPP, and stimulated at the lowest ones. The opposite concentrationresponse pattern was observed when fibrinogen was used as substrate. © 1992 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026670350&origin=inward; http://dx.doi.org/10.1007/bf02899703; http://www.ncbi.nlm.nih.gov/pubmed/1360722; http://link.springer.com/10.1007/BF02899703; http://www.springerlink.com/index/pdf/10.1007/BF02899703; http://www.springerlink.com/index/10.1007/BF02899703; https://dx.doi.org/10.1007/bf02899703; https://link.springer.com/article/10.1007/BF02899703
Springer Nature
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