Biochemical and clinical effects of an antioxidative supplementation of geriatric patients - A double blind study
Biological Trace Element Research, ISSN: 0163-4984, Vol: 20, Issue: 1-2, Page: 135-151
1989
- 73Citations
- 18Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations73
- Citation Indexes66
- 66
- CrossRef59
- Policy Citations7
- Policy Citation7
- Captures18
- Readers18
- 18
Article Description
Ninety seven geriatric patients from two Danish homes for old people accepted to participate in a blinded experiment designed to counteract ageing phenomena. The subjects were split into two groups, i.e., the verum and the placebo group. The verum group received daily for one year an antioxidative cocktail consisting of: 300 μg selenium as l-selenomethionine, 45 mg zinc, 270 mg vitamin C, 2.7 mg vitamin A, 6 mg vitamin B-6, and 465 mg vitamin E (d-alfatocopherol). Furthermore, in order to enhance exchange in polyenoic acids, each subject received daily 250 mg gamma-linolenic acid. The placebo groups received similar looking pills and capsules without the active components. During one year in the verum group, the whole blood selenium, the hydrogen-dependent glutathione peroxidase (GSH-Px) of erythrocytes, and the vitamin E level in serum was found increased compared to the pretreatment values and to the placebo group. No change could be traced in the t-butylhydroperoxide dependent GSH-Px, an enzyme that also assays the glutathione-s-transferase. During the same period of time, the fasting levels of serum fatty acid and the content of lipofuscin in erythrocytes were estimated. Compared to the pretreatment values, the lipofuscin level declined significantly and the level of w-3 penta- and hexaenoic acids increased in the verum, but not in the placebo group. During the study period, slight, but significant improvements in psychological scores could be traced. Furthermore, the assays of bloodflow in different areas of the brain surface (i.e., the ISI values) revealed a general trend to improvement in all areas, when the ISI values were compared during treatment with the pretreatment values and the values in the placebo group. © 1989 The Humana Press Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024506701&origin=inward; http://dx.doi.org/10.1007/bf02919106; http://www.ncbi.nlm.nih.gov/pubmed/2484393; http://link.springer.com/10.1007/BF02919106; http://www.springerlink.com/index/pdf/10.1007/BF02919106; http://www.springerlink.com/index/10.1007/BF02919106; https://dx.doi.org/10.1007/bf02919106; https://link.springer.com/article/10.1007/BF02919106
Springer Nature
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