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Streptomycin and N-Methyl-N'-nitro-N-nitroso-guanidine inhibit incorporation ofC-precursors of macromolecule synthesis in Euglena gracillis

Folia Microbiologica, ISSN: 1874-9356, Vol: 33, Issue: 6, Page: 466-473
1988
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Article Description

Streptomycin and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) cause a 100% hereditary bleaching of Euglena gracilis. In spite of the outcomes being the same, the corresponding mechanisms differ. By investigating the incorporation of theC-labelled precursors of macromolecule synthesis we showed streptomycin to inhibit the synthesis of nucleic acids and proteins to the same extent (56%), whereas in the case of MNNG a 66% inhibition of nucleic acid synthesis and a 24% one of protein synthesis were observed. © 1988 Institute of Microbiology, Academy of Sciences of the Czech Republic.

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