PlumX Metrics
Embed PlumX Metrics

The molecular mechanism underlying the acquisition of the antiestrogen-resistant phenotype in breast cancer

Breast Cancer, ISSN: 1340-6868, Vol: 5, Issue: 1, Page: 25-31
1998
  • 0
    Citations
  • 0
    Usage
  • 2
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Breast cancer is thought to develope as an estrogen-dependent tumor. Approximately 30% of breast cancers can be treated by agents that block estrogen. However, all breast cancers have been known to acquire the hormone therapy-resistant phenotype with ultimate fatal results. Recent progress in breast cancer research has provided the important clues for elucidating the molecular mechanism of this conversion. The presence of the cross-talk between estrogen signaling and other mitogen-dependent signaling has been clarified at the estrogen receptor level. In addition, an estrogen-dependent transcriptional control mechanism has been characterized in detail. These breakthrough and the development of a pure antiestrogen would make it possible to consider the more sophisticated hormone therapy. In this review article, I summarized the current findings which seem to be essential in the treatment of breast cancer.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know