Comparative absorption kinetics of intramuscular midazolam and diazepam
Canadian Journal of Anaesthesia, ISSN: 0832-610X, Vol: 43, Issue: 5, Page: 450-455
1996
- 35Citations
- 27Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations35
- Citation Indexes35
- 35
- CrossRef27
- Captures27
- Readers27
- 27
Article Description
Purpose: This study investigates the rate and extent of absorption following intramuscular injection of midazolam and diazepam. Methods: Four healthy male volunteers were recruited in this randomized three-way cross-over study. On one occasion each subject received simultaneous im injections of 5 mg midazolam and 10 mg diazepam in separate deltoid muscles. On two other separate occasions each subject received an iv infusion of 7.5 mg midazolam and 30 mg diazepam over five minutes. Frequent arterial blood samples were collected for up to two hours and venous blood samples were collected for up to 24 hours for midazolam and ten days for diazepam. A gas chromatography assay was used to determine the plasma concentrations of midazolam and diazepam. The im absorption profiles were estimated using constrained least-squares deconvolution. Results: There were substantial intersubject variabilities in the estimated pharmacokinetic parameters (volumes and clearances) of intravenous midazolam and diazepam. The mean (± sd) time to peak plasma concentration (C(max)) was shorter for im midazolam (17.5 ± 6.5 min) relative to diazepam (33.8 ± 7.5 min). The mean (± sd) time to peak absorption rate was also shorter for midazolam (9 ± 2 vs 13.8 ± 7.5 min). The peak rate of absorption was identical (0.18 mg · min) and bioavailability was 1.0 for both drugs. Conclusions: We conclude that midazolam has more rapid absorption than diazepam following in administration.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030001444&origin=inward; http://dx.doi.org/10.1007/bf03018105; http://www.ncbi.nlm.nih.gov/pubmed/8723850; http://link.springer.com/10.1007/BF03018105; http://www.springerlink.com/index/pdf/10.1007/BF03018105; https://dx.doi.org/10.1007/bf03018105; https://link.springer.com/article/10.1007/BF03018105; http://www.springerlink.com/index/10.1007/BF03018105
Springer Science and Business Media LLC
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