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Genetical studies on the skeleton of the mouse - VII. congenital hydrocephalus

Journal of Genetics, ISSN: 0022-1333, Vol: 51, Issue: 2, Page: 327-358
1953
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The development of the skeleton of the mutant congenital hydrocephalus in the mouse has been investigated. The condition is basically due to a disturbance of the mesenchymal skeleton which is generalized. The mesenchymal condensations are reduced in size, this being more marked in some parts of the skeleton than in others. Where reduction is not too drastic, cartilages of reduced size are laid clown, often with a delay of a clay or so as compared with the normal. Once laid down, cartilages grow at a normal rate and hence remain smaller than normal to about the same extent throughout. Though often some what retarded, the cartilage is histologically normal. In some places where the reduction of the mesenchymal condensations is too great, no cartilage is formed; the missing parts may, however, be represented by fibrous tissue. Anomalous fusions between neighbouring cartilages occur in several localities. While the extensive abnormalities of the cartilaginous skeleton are secondary to the reduction of the mesenchymal condensations, the more scattered abnormalities of the osseous skeleton are partly clue to those of the cartilaginous skeleton. Some bones are absent because their cartilaginous predecessors are absent. © 1953 Indian Academy of Sciences.

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