Dopamine and reward: The anhedonia hypothesis 30 years on
Neurotoxicity Research, ISSN: 1029-8428, Vol: 14, Issue: 2-3, Page: 169-183
2008
- 427Citations
- 618Captures
- 5Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations427
- Citation Indexes424
- 424
- CrossRef243
- Policy Citations3
- Policy Citation3
- Captures618
- Readers618
- 618
- Mentions5
- References3
- Wikipedia3
- News Mentions2
- News2
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Article Description
The anhedonia hypothesis - that brain dopamine plays a critical role in the subjective pleasure associated with positive rewards - was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward. The hypothesis called to attention the apparent paradox that neuroleptics, drugs used to treat a condition involving anhedonia (schizophrenia), attenuated in laboratory animals the positive reinforcement that we normally associate with pleasure. The hypothesis held only brief interest for psychiatrists, who pointed out that the animal studies reflected acute actions of neuroleptics whereas the treatment of schizophrenia appears to result from neuroadaptations to chronic neuroleptic administration, and that it is the positive symptoms of schizophrenia that neuroleptics alleviate, rather than the negative symptoms that include anhedonia. Perhaps for these reasons, the hypothesis has had minimal impact in the psychiatric literature. Despite its limited heuristic value for the understanding of schizophrenia, however, the anhedonia hypothesis has had major impact on biological theories of reinforcement, motivation, and addiction. Brain dopamine plays a very important role in reinforcement of response habits, conditioned preferences, and synaptic plasticity in cellular models of learning and memory. The notion that dopamine plays a dominant role in reinforcement is fundamental to the psychomotor stimulant theory of addiction, to most neuroadaptation theories of addiction, and to current theories of conditioned reinforcement and reward prediction. Properly understood, it is also fundamental to recent theories of incentive motivation. © Springer 2008.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=63249095013&origin=inward; http://dx.doi.org/10.1007/bf03033808; http://www.ncbi.nlm.nih.gov/pubmed/19073424; http://link.springer.com/10.1007/BF03033808; https://dx.doi.org/10.1007/bf03033808; https://link.springer.com/article/10.1007/BF03033808
Springer Nature
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