Pathogenesis of renal interstitial fibrosis
Medizinische Klinik, ISSN: 0723-5003, Vol: 92, Issue: 10, Page: 582-588
1997
- 4Citations
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations4
- Citation Indexes4
- CrossRef1
Article Description
Method: Using cell cultures it was examined whether any in vivo changes in proliferation and function of fibroblasts are also detectable in cell cultures and whether, due to their persistency, they are of fundamental importance for the development of renal interstitial fibrosis. Results: The comparison of the proliferation in cell cultures established 5 and 21 days after UUO showed that the cultures of the two experimental groups behave similarly. Consequently, the action of acute inflammatory processes on fibroblast proliferation without any existing fibrosis is comparable with that of pronounced fibrosis in the animal model. High concentrations of fetal calf serum in the culture medium cause a stimulation of the cell proliferation as well as a selection of mitotically active differentiation stages of fibroblasts. Conclusion: Obviously, the loss of inhibition of the fibroblast proliferation under the conditions of cell culture causes similar changes to those effected by pathogenic mechanisms in the kidneys of rats with UUO. If the behaviour of fibroblasts in organs is to be assessed using results of cell culture experiments, the stimulating action of the culture conditions and the missing influence of other cells present in the tissue should be considered. These factors make the recognition of remaining differences between cells from normal and damaged kidneys more difficult under the conditions of primary cell cultures.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030732939&origin=inward; http://dx.doi.org/10.1007/bf03044783; http://www.ncbi.nlm.nih.gov/pubmed/9446005; http://link.springer.com/10.1007/BF03044783; http://www.springerlink.com/index/pdf/10.1007/BF03044783; https://dx.doi.org/10.1007/bf03044783; https://link.springer.com/article/10.1007/BF03044783; http://www.springerlink.com/index/10.1007/BF03044783
Springer Nature
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