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Effect of triiodothyronine administration in experimental myocardial injury

Journal of Endocrinological Investigation, ISSN: 1720-8386, Vol: 18, Issue: 9, Page: 702-709
1995
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Article Description

Twelve healthy pigs were subjected to a 20-min, period of regional myocardial ischemia by snaring the left anterior descending coronary artery (LAD) between its first and second diagonal branches. The resulting myocardial injury caused significant acute hemodynamic impairments. Cardiac index declined significantly during reperfusion interval and returned to preischemic level by postoperative day 7. Plasma total triiodothyronine (TT), free triiodothyronine (FT) and free fatty acid (FFA) decreased gradually and reached the nadir at 6 h after LAD occlusion. In contrast, plasma reverse triiodothyronine (rT) increased progressively after LAD occlusion and reperfusion. To investigate the effect of T on ischémic myocardium, T (0.2 μg/kg/dose; n=5) or saline (placebo; n=6) was administered immediately, 30 min, 60 min, 90 min, and 120 min after reperfusion. Plasma TT and FT increased dramatically after triiodothyronine supplement but declined to presichemic level at six h after LAD occlusion. The pigs treated with T demonstrated a rapid improvement in cardiac index over the reperfusion interval, whereas cardiac index in the placebo group remained depressed. Myocardial oxygen consumption estimated by rate pressure product showed no difference between placebo and T-treated groups. Oxygen extraction as O saturation difference between aorta and coronary sinus was less in T-treated group. Nine pigs (four in the T-treated group and five in the placebo group) were subjected to euthanasia with hypertonic KCI solution on postoperative day 7. Myocardial infarct size determined by triphenyltetrazolium chloride (TTC) tissue enzyme staining technique was not significantly different between T-treated and placebo groups. We concluded that this animal model is a useful model of myocardial injury simulating “euthyroid sick syndrome” as seen in patients with cardiopulmonary bypass, and T supplementation after reperfusion significantly enhanced postischemic left ventricular functional recovery but did not affect myocardial oxygen consumption and myocardial infarct size. © 1995, Italian Society of Endocrinology (SIE). All rights reserved.

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