TAX1BP1 regulates the apoptosis of renal tubular epithelial cells in ischemia/reperfusion injury via the NF-kB/PMAIP1 signaling pathway
Inflammation Research, ISSN: 1420-908X, Vol: 74, Issue: 1, Page: 9
2025
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Background: The pathogenesis of acute kidney injury (AKI) is not fully understood. Tax1-binding protein 1 (TAX1BP1) modulates inflammation and apoptosis through the NF-kB signaling pathway, however, its specific role in ischemic AKI remains unclear. Methods: We injected a TAX1BP1 overexpression plasmid into the tail vein of male C57BL/6 mice, followed by clamping the bilateral renal arteries to induce AKI. Additionally, TAX1BP1 overexpression and silencing vectors were transfected into NRK52E cells to establish an in vitro hypoxia-reoxygenation model. Renal tubular necrosis was assessed using PAS and H&E staining. Expression levels of TAX1BP1, caspase-3, Bcl2, phosphorylated p65, and total p65 were measured through Western blot in both models. RT-PCR was used to evaluate KIM-1, NGAL, IL-6, and TNFα expression, while TUNEL staining detected apoptosis in renal tubular epithelial cells. RNA sequencing identified potential TAX1BP1 targets, which were validated via Western blot and RT-PCR. Results: Our results indicate that TAX1BP1 significantly influences ischemic AKI by modulating apoptosis and inflammation in kidney tissues. In vitro studies confirmed its critical role in renal tubular epithelial cell apoptosis and inflammation through NF-kB activation, potentially via PMAIP1. Conclusion: TAX1BP1 may protect renal tubular epithelial cells by targeting PMAIP1 through the NF-kB signaling pathway in ischemic AKI.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85214262454&origin=inward; http://dx.doi.org/10.1007/s00011-024-01976-4; http://www.ncbi.nlm.nih.gov/pubmed/39762558; https://link.springer.com/10.1007/s00011-024-01976-4; https://dx.doi.org/10.1007/s00011-024-01976-4; https://link.springer.com/article/10.1007/s00011-024-01976-4
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know