Molecular processes involved in B cell acute lymphoblastic leukaemia
Cellular and Molecular Life Sciences, ISSN: 1420-9071, Vol: 75, Issue: 3, Page: 417-446
2018
- 52Citations
- 231Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations52
- Citation Indexes51
- 51
- CrossRef47
- Policy Citations1
- 1
- Captures231
- Readers231
- 231
Review Description
B cell leukaemia is one of the most frequent malignancies in the paediatric population, but also affects a significant proportion of adults in developed countries. The majority of infant and paediatric cases initiate the process of leukaemogenesis during foetal development (in utero) through the formation of a chromosomal translocation or the acquisition/deletion of genetic material (hyperdiploidy or hypodiploidy, respectively). This first genetic insult is the major determinant for the prognosis and therapeutic outcome of patients. B cell leukaemia in adults displays similar molecular features as its paediatric counterpart. However, since this disease is highly represented in the infant and paediatric population, this review will focus on this demographic group and summarise the biological, clinical and epidemiological knowledge on B cell acute lymphoblastic leukaemia of four well characterised subtypes: t(4;11) MLL-AF4, t(12;21) ETV6-RUNX1, t(1;19) E2A-PBX1 and t(9;22) BCR-ABL1.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85027682596&origin=inward; http://dx.doi.org/10.1007/s00018-017-2620-z; http://www.ncbi.nlm.nih.gov/pubmed/28819864; http://link.springer.com/10.1007/s00018-017-2620-z; https://dx.doi.org/10.1007/s00018-017-2620-z; https://link.springer.com/article/10.1007/s00018-017-2620-z
Springer Science and Business Media LLC
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