RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity
Cellular and Molecular Life Sciences, ISSN: 1420-9071, Vol: 78, Issue: 7, Page: 3709-3724
2021
- 11Citations
- 35Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- Captures35
- Readers35
- 35
Article Description
Guanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important regulatory roles in fundamental biological processes such as DNA replication, transcription, and translation, while aberrant G-quadruplex formation is linked to genome instability and cancer. Understanding the biological functions played by G-quadruplexes requires detailed knowledge of their protein interactome. Here, we report that both RNA and DNA G-quadruplexes are bound by human Dicer in vitro. Using in vitro binding assays, mutation studies, and computational modeling we demonstrate that G-quadruplexes can interact with the Platform–PAZ–Connector helix cassette of Dicer, the region responsible for anchoring microRNA precursors (pre-miRNAs). Consequently, we show that G-quadruplexes efficiently and stably inhibit the cleavage of pre-miRNA by Dicer. Our data highlight the potential of human Dicer for binding of G-quadruplexes and allow us to propose a G-quadruplex-driven sequestration mechanism of Dicer regulation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102556804&origin=inward; http://dx.doi.org/10.1007/s00018-021-03795-w; http://www.ncbi.nlm.nih.gov/pubmed/33733306; https://link.springer.com/10.1007/s00018-021-03795-w; https://dx.doi.org/10.1007/s00018-021-03795-w; https://link.springer.com/article/10.1007/s00018-021-03795-w
Springer Science and Business Media LLC
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