Synthesis and biological evaluation of some stilbene-based analogues
Medicinal Chemistry Research, ISSN: 1054-2523, Vol: 20, Issue: 8, Page: 1158-1163
2011
- 11Citations
- 11Captures
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Article Description
The phytoalexin 3,5,40-trihydroxy-trans-stilbene (resveratrol) has attracted considerable attention from biologists and chemists due to its diverse biological properties. Owing to the biological importance of this compound, we have synthesized new stilbene-based analogues by using substituted benzyl chlorides and substituted aldehydes in a two-step reaction and evaluated their in vitro antioxidant, antibacterial and antifungal potential. Most of the compounds displayed moderate to significant radical scavenging activity. (E)-1-(3,4-difluorophenyl)-2-(4-fluorophenyl) ethene (4c) showed nearer equipotent antibacterial activity against Staphylococcus aureus. (E)-1,2-bis (4-fluorophenyl)ethene (4a), (E)-1-(3-fluorophenyl)-2-(4-fluorophenyl)ethene (4b), (E)-1-(2,4-dichlorophenyl)-2-(3, 4-dichlorophenyl)ethene (4f), (E)-1-(2,4-dichlorophenyl)-2-(3-chlorophenyl)ethene (4g), (E)-1-(2,4- dichlorophenyl)-2-(4-fluorophenyl)ethene (4j) (E)-1-(4-fluorophenyl)-2-(3- chlorophenyl)ethene (4l) and (E)-1-(4-chlorophenyl)-2-(4-fluorophenyl)ethene (4n) inhibited the growth of Penicillium chrysogenum. © Springer Science+Business Media, LLC 2010.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80054718268&origin=inward; http://dx.doi.org/10.1007/s00044-010-9450-y; http://link.springer.com/10.1007/s00044-010-9450-y; http://link.springer.com/content/pdf/10.1007/s00044-010-9450-y; http://link.springer.com/content/pdf/10.1007/s00044-010-9450-y.pdf; http://link.springer.com/article/10.1007/s00044-010-9450-y/fulltext.html; http://www.springerlink.com/index/10.1007/s00044-010-9450-y; http://www.springerlink.com/index/pdf/10.1007/s00044-010-9450-y; https://dx.doi.org/10.1007/s00044-010-9450-y; https://link.springer.com/article/10.1007/s00044-010-9450-y
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