Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
Medicinal Chemistry Research, ISSN: 1054-2523, Vol: 21, Issue: 9, Page: 2217-2222
2012
- 46Citations
- 30Captures
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Article Description
In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin. © Springer Science+Business Media, LLC 2011.
Bibliographic Details
Springer Science and Business Media LLC
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