Synthesis of benzothiazole derivatives having acetamido and carbothioamido pharmacophore as anticonvulsant agents
Medicinal Chemistry Research, ISSN: 1054-2523, Vol: 21, Issue: 9, Page: 2661-2670
2012
- 40Citations
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
A new series of N-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (3a-h) and N-(6-chlorobenzothiazol-2-yl)-2-(substituted-benzylidene) hydrazinecarbothioamides (5a-h) were synthesized and characterized by IR, HNMR, mass and elemental analysis. In vivo anticonvulsant and acute toxicity screening of all the synthesized compounds showed morpholino (3f) and imidazolyl (3g) derivatives as promising anticonvulsant lead. Furthermore, In silico druglikeness parameters have also been investigated for filtering out the likelihood of poor drug absorption or brain penetration. 3D four-point pharmacophore measurements of compounds were also carried out to match these with established anticonvulsants agents. © Springer Science+Business Media, LLC 2011.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866352524&origin=inward; http://dx.doi.org/10.1007/s00044-011-9791-1; http://link.springer.com/10.1007/s00044-011-9791-1; http://link.springer.com/content/pdf/10.1007/s00044-011-9791-1; http://link.springer.com/content/pdf/10.1007/s00044-011-9791-1.pdf; http://link.springer.com/article/10.1007/s00044-011-9791-1/fulltext.html; https://dx.doi.org/10.1007/s00044-011-9791-1; https://link.springer.com/article/10.1007/s00044-011-9791-1; http://www.springerlink.com/index/10.1007/s00044-011-9791-1; http://www.springerlink.com/index/pdf/10.1007/s00044-011-9791-1
Springer Science and Business Media LLC
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