Synthesis of new N-arylamino(2-furyl)methylphosphonic acid diesters, and in vitro evaluation of their cytotoxicity against esophageal cancer cells
Medicinal Chemistry Research, ISSN: 1054-2523, Vol: 22, Issue: 2, Page: 852-860
2013
- 21Citations
- 11Captures
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Article Description
N-Furfurylideneanilines and N-arylamino(2-furyl)methylphosphonates with tolyl and anisyl moieties were synthesized by the addition of phosphites to azomethine bond of corresponding Schiff bases and their NMR spectroscopic properties were investigated. Then, they were analyzed in the point of view of their influence on KYSE 30, KYSE 150, and KYSE 270 esophageal cancer cell lines and on immortalized esophageal cell line HET 1 A as a control group. Toxicity was evaluated by MTT assay. Among 11 compounds, a few of them demonstrated influence on cancer cells being neutral toward the control, but only one aminophosphonate had IC lower than 100 μM and acted as a potential anticancer drug. Some approaches to structure-activity relation were performed. © 2012 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873991051&origin=inward; http://dx.doi.org/10.1007/s00044-012-0065-3; http://link.springer.com/10.1007/s00044-012-0065-3; http://link.springer.com/content/pdf/10.1007/s00044-012-0065-3; http://link.springer.com/content/pdf/10.1007/s00044-012-0065-3.pdf; http://link.springer.com/article/10.1007/s00044-012-0065-3/fulltext.html; https://dx.doi.org/10.1007/s00044-012-0065-3; https://link.springer.com/article/10.1007/s00044-012-0065-3; http://www.springerlink.com/index/10.1007/s00044-012-0065-3; http://www.springerlink.com/index/pdf/10.1007/s00044-012-0065-3
Springer Science and Business Media LLC
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