Synthesis, characterization and in vitro antimicrobial evaluation of some novel hydrazone derivatives bearing pyrimidinyl and pyrazolyl moieties as a promising heterocycles
Medicinal Chemistry Research, ISSN: 1554-8120, Vol: 24, Issue: 6, Page: 2551-2560
2015
- 30Citations
- 35Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
In the present investigation, ten new 2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)-1-(4,6-dimethylpyrimidin-2-yl)hydrazine (3a-j) having pyrimidinyl and pyrazolyl moieties were synthesized. Structures of all compounds were confirmed by their spectral and elemental data. Most of the tested compounds were found to be significantly more effective against bacterial strains Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa than the reference drug ciprofloxacin. All the newly synthesized compounds were found to be more potent antifungal agents than reference drug against Candida albicans, whereas except 3e all other compounds also shown good activity against Saccharomyces cerevisiae.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930927898&origin=inward; http://dx.doi.org/10.1007/s00044-014-1313-5; http://link.springer.com/10.1007/s00044-014-1313-5; http://link.springer.com/content/pdf/10.1007/s00044-014-1313-5; http://link.springer.com/content/pdf/10.1007/s00044-014-1313-5.pdf; http://link.springer.com/article/10.1007/s00044-014-1313-5/fulltext.html; https://dx.doi.org/10.1007/s00044-014-1313-5; https://link.springer.com/article/10.1007/s00044-014-1313-5
Springer Science and Business Media LLC
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