Synthesis and anti-inflammatory intestinal activity of new glucocorticoid derivatives
Medicinal Chemistry Research, ISSN: 1554-8120, Vol: 29, Issue: 2, Page: 206-216
2020
- 3Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Glucocorticoids (GCs) are used worldwide in the treatment of chronic inflammatory diseases. This study describes the synthesis of new glucocorticoid derivatives and evaluates anti-inflammatory activity in rat models with ulcerative colitis (UC). Six compounds (5a–f) were synthetized using the molecular hybridization strategy with yields of 40–80%. The compounds 5e and 5f showed a total regression of ulceration in 83.3% and 75% of treated animals, respectively. Moreover, 5e improved several clinical signs, such as weight gain and survival rates. The compounds 5a and 5c showed total regression of ulceration in 33.3% of the rats. This is higher than prednisolone. Glucocorticoid derivatives showed potential anti-inflammatory intestinal activity with regression of ulceration in colitis.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85075368890&origin=inward; http://dx.doi.org/10.1007/s00044-019-02474-7; http://link.springer.com/10.1007/s00044-019-02474-7; http://link.springer.com/content/pdf/10.1007/s00044-019-02474-7.pdf; http://link.springer.com/article/10.1007/s00044-019-02474-7/fulltext.html; https://dx.doi.org/10.1007/s00044-019-02474-7; https://link.springer.com/article/10.1007/s00044-019-02474-7
Springer Science and Business Media LLC
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