HBM-I values for Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic acid (PFOS) in blood plasma-Statement of the German Human Biomonitoring Commission (HBM Commission)
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, ISSN: 1437-1588, Vol: 61, Issue: 4, Page: 474-487
2018
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Article Description
In 2016, the German Human Biomonitoring Commission (HBM-C) published a statement on its decision to derive HBM-I values for Perfluorooctanoic acid (PFOA) and Perfluo-rooctanesulfonic acid (PFOS)*. The objective of this manuscript is to describe the methods and the prinicipal studies, on which this derivation was seen for fertility and pregnancy, weights of newborns at birth, lipid metabolism, immunity, sex hormones and age at puberty/ menarche, thyroid hormones, onset of menopause as well as uric acid metabolism. Significant contrasts were reported for human blood plasma concentrations between 1 and 10 ng PFOA/ml, and 1-15 ng PFOS/ml, respectively. Within the reported ranges, the HBM-C has decided to set the HBM-I-values at 2 ng PFOA/ ml and 5 ng PFOS/ml blood plasma. The pathomechanisms involved do currently not seem to be clarified sufficiently to provide an explanation of the effects observed. Con-sistency of toxicological and epidemiological data has been considered. The data available do not appear to show proof of a genotoxicity of PFOA and PFOS.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85063030008&origin=inward; http://dx.doi.org/10.1007/s00103-018-2709-z; http://www.ncbi.nlm.nih.gov/pubmed/29589091; http://link.springer.com/10.1007/s00103-018-2709-z; https://dx.doi.org/10.1007/s00103-018-2709-z; https://link.springer.com/article/10.1007/s00103-018-2709-z
Springer Science and Business Media LLC
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