Regulation of angiogenesis by oxygen sensing mechanisms
Journal of Molecular Medicine, ISSN: 0946-2716, Vol: 87, Issue: 6, Page: 549-560
2009
- 117Citations
- 84Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations117
- Citation Indexes116
- 116
- CrossRef92
- Policy Citations1
- Policy Citation1
- Captures84
- Readers84
- 84
Review Description
The choices for blood vessels to undergo angiogenesis or stay quiescent are mostly determined by the status of tissue oxygenation. A major link between tissue hypoxia and active angiogenesis is the accumulation of hypoxia-inducible factor (HIF)-α subunits which play a major role in the transcriptional activation of genes encoding angiogenic factors. HIF-α abundance is negatively regulated by a subfamily of dioxygenases referred to as prolyl hydroxylase domain-containing proteins (PHDs) which use O as a substrate to hydroxylate HIF-α subunits and hence tag them for rapid degradation. Under hypoxic conditions, HIF-α subunits accumulate due to reduced hydroxylation efficiency and form transcriptionally active heterodimers with HIF-1ß to activate the expression of angiogenic factors and other proteins important for cellular adaptation to hypoxia. Angiogenesis is regulated by a combination of at least two different mechanisms. The paracrine mechanism is mediated by non-endothelial expression of angiogenic factors such as vascular endothelial growth factor (VEGF)-A, which in turn interact with endothelial cell surface receptors to initiate angiogenic activities. In the autocrine mechanism, endothelial cell themselves are induced to express VEGF-A, which collaborate with the paracrine mechanism to support angiogenesis and protect vascular integrity. Because of critical roles of PHDs and HIFs in regulating angiogenic activities, studies are underway to assess their candidacy as targets for angiogenesis therapies. © 2009 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67349119514&origin=inward; http://dx.doi.org/10.1007/s00109-009-0458-z; http://www.ncbi.nlm.nih.gov/pubmed/19288062; http://link.springer.com/10.1007/s00109-009-0458-z; https://dx.doi.org/10.1007/s00109-009-0458-z; https://link.springer.com/article/10.1007/s00109-009-0458-z; http://www.springerlink.com/index/10.1007/s00109-009-0458-z; http://www.springerlink.com/index/pdf/10.1007/s00109-009-0458-z
Springer Science and Business Media LLC
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