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Modern treatment of childhood epilepsy: Update

Monatsschrift fur Kinderheilkunde, ISSN: 1433-0474, Vol: 165, Issue: 6, Page: 519-537
2017
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Article Description

In individual cases of patients with an appropriate risk constellation, epilepsy can be diagnosed even after one unprovoked seizure. The exact classification of seizures and epilepsy is the basic prerequisite for a successful therapy. According to the latest classification proposal by the International League Against Epilepsy, epilepsies are differentiated based on seizure types, etiology and syndromes, by taking comorbidities into consideration. More than 20 substances are available in Germany for antiepileptic drug treatment; however, most of the newer drugs are often not licensed for use in children and this particularly applies to monotherapy. Pharmacoresistance is defined as the failure of two attempts at treatment with adequately selected antiepileptic drugs. In addition to drug therapy, epilepsy surgery, neurostimulation and ketogenic diets are further options for the differential therapy.

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