Improved fibrinolysis by an intensive lifestyle intervention in subjects with impaired glucose tolerance. The Finnish Diabetes Prevention Study
Diabetologia, ISSN: 0012-186X, Vol: 48, Issue: 11, Page: 2248-2253
2005
- 46Citations
- 69Captures
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Metrics Details
- Citations46
- Citation Indexes40
- 40
- CrossRef29
- Policy Citations6
- Policy Citation6
- Captures69
- Readers69
- 69
Article Description
Aims/hypothesis: The aim of this study was to investigate the effects of lifestyle intervention on the levels of plasminogen activator inhibitor (PAI-1) and fibrinogen in subjects participating in the Finnish Diabetes Prevention Study (DPS). Methods: In five DPS centres, 321 subjects with impaired glucose tolerance (intervention group, n=163; control group, n=158) had their PAI-1 and fibrinogen levels measured at baseline and at the 1-year follow-up. Additional 3-year follow-up assessments were carried out in a sample of 97 subjects in one of the DPS centres (Turku). The intervention programme included an intensive lifestyle intervention aiming at weight reduction, healthy diet and increased physical activity. Results: During the first intervention year, PAI-1 decreased by 31% in the intervention group but showed no change in the control group (p<0.0001). In the Turku subgroup, the decrease in PAI-1 persisted throughout the 3-year follow-up. Changes in PAI-1 were associated with the number of lifestyle changes made during the first year (p=0.008). Weight reduction was the most important factor explaining the decrease in PAI-1. Changes in fibrinogen levels did not differ between the groups. Conclusions/interpretation: In addition to the previously reported reduction in the risk of type 2 diabetes in DPS participants with impaired glucose tolerance, the intensive dietary and exercise intervention had beneficial long-term effects on fibrinolysis as indicated by the reduced levels of PAI-1. These results suggest that elevated PAI-1 levels in obese subjects with impaired glucose tolerance are mostly reversible by lifestyle changes, especially those geared to weight reduction. © Springer-Verlag 2005.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27744600828&origin=inward; http://dx.doi.org/10.1007/s00125-005-1938-5; http://www.ncbi.nlm.nih.gov/pubmed/16205886; http://link.springer.com/10.1007/s00125-005-1938-5; http://www.springerlink.com/index/10.1007/s00125-005-1938-5; http://www.springerlink.com/index/pdf/10.1007/s00125-005-1938-5; https://dx.doi.org/10.1007/s00125-005-1938-5; https://link.springer.com/article/10.1007/s00125-005-1938-5
Springer Science and Business Media LLC
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