Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis
Intensive Care Medicine, ISSN: 1432-1238, Vol: 37, Issue: 1, Page: 86-96
2011
- 333Citations
- 386Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations333
- Citation Indexes320
- 320
- CrossRef136
- Policy Citations8
- Policy Citation8
- Clinical Citations5
- PubMed Guidelines5
- Captures386
- Readers386
- 385
- Mentions2
- News Mentions2
- News2
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Article Description
Purpose: To determine the effect of random assignment to fluid resuscitation with albumin or saline on organ function and mortality in patients with severe sepsis. Methods: Pre-defined subgroup analysis of a randomized controlled trial conducted in the intensive care units of 16 hospitals in Australia and New Zealand. Results: Of 1,218 patients with severe sepsis at baseline, 603 and 615 were assigned to receive albumin and saline, respectively. The two groups had similar baseline characteristics. During the first 7 days mean arterial pressure was similar in the two groups, but patients assigned albumin had a lower heart rate on days 1 and 3 (p = 0.002 and p = 0.03, respectively) and a higher central venous pressure on days 1–3 (p <0.005 each day). There was no difference in the renal or total Sequential Organ Failure Assessment score of the two groups; 113/603 (18.7%) of patients assigned albumin were treated with renal replacement therapy compared to 112/615 (18.2%) assigned saline (p = 0.98).The unadjusted relative risk of death for albumin versus saline was 0.87 [95% confidence interval (CI) 0.74–1.02] for patients with severe sepsis and 1.05 (0.94–1.17) for patients without severe sepsis (p = 0.06 for heterogeneity). From multivariate logistic regression analysis adjusting for baseline factors in patients with complete baseline data (919/1,218, 75.5%), the adjusted odds ratio for death for albumin versus saline was 0.71 (95% CI: 0.52–0.97; p = 0.03). Conclusions: Administration of albumin compared to saline did not impair renal or other organ function and may have decreased the risk of death.
Bibliographic Details
10.1007/s00134-010-2039-6; 10.3410/f.6136961.8355054; 10.3410/f.6136961.9000056; 10.3410/f.6136961.6174059
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78751646535&origin=inward; http://dx.doi.org/10.1007/s00134-010-2039-6; http://www.ncbi.nlm.nih.gov/pubmed/20924555; https://facultyopinions.com/prime/6136961#eval8355054; http://dx.doi.org/10.3410/f.6136961.8355054; https://facultyopinions.com/prime/6136961#eval9000056; http://dx.doi.org/10.3410/f.6136961.9000056; https://facultyopinions.com/prime/6136961#eval6174059; http://dx.doi.org/10.3410/f.6136961.6174059; http://link.springer.com/10.1007/s00134-010-2039-6; https://dx.doi.org/10.1007/s00134-010-2039-6; https://link.springer.com/article/10.1007/s00134-010-2039-6; http://www.springerlink.com/index/10.1007/s00134-010-2039-6; http://www.springerlink.com/index/pdf/10.1007/s00134-010-2039-6; https://link.springer.com/content/pdf/10.1007%2Fs00134-010-2039-6.pdf; http://europepmc.org/abstract/med/20924555; http://f1000.com/6136961#eval9000056; http://f1000.com/6136961#eval6174059; http://f1000.com/6136961#eval8355054; http://link.springer.com/article/10.1007%2Fs00134-010-2039-6
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