Lithium use and risk of fracture: a systematic review and meta-analysis of observational studies
Osteoporosis International, ISSN: 1433-2965, Vol: 30, Issue: 2, Page: 257-266
2019
- 20Citations
- 11Usage
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations20
- Citation Indexes20
- 20
- Usage11
- Abstract Views11
- Captures26
- Readers26
- 26
Article Description
Summary: This systematic review and meta-analysis summarized the results from nine eligible observational studies. Lithium use was significantly associated with a decrease risk of fractures. Introduction: The association between lithium use and risk of fracture is uncertain. To date, there have been no meta-analyses that have studied the association between the two. We conducted a systematic review and meta-analysis to examine the effect of lithium medication on the risk of fracture. Methods: A comprehensive literature search was performed in PubMed, Embase, and MEDLINE to include eligible observational studies. Three reviewers conducted the literature search, study selection, study appraisal, and data abstraction independently. Random effects models were used to obtain the overall estimate for meta-analysis. Cochran’s Q and Higgins’ I were used to assess heterogeneity. A funnel plot and Egger’s regression test were employed to assess publication bias. Results: Of the 3819 studies that were identified by our search strategy, eight were eligible for the systematic review, while seven of them qualified for the meta-analysis. In studies that reported risk ratio (RR) of fracture as an outcome (five studies [n = 1,134,722]), lithium use was associated with a 20% decrease in risk of fracture (RR = 0.80; 95% CI, 0.73–0.87; p < 0.01). A decreased risk of fracture associated with lithium was also observed in studies that adjusted for previous fractures (RR = 0.81; 95% CI, 0.73–0.89; p < 0.01). The decreased risk of fracture associated with lithium use remained consistent in all the analyses with different inclusion criteria. Neither significant heterogeneity nor significant publication bias was observed. Conclusion: The present systematic review and meta-analysis demonstrated that lithium use was associated with a significant decreased risk of fracture.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85055972723&origin=inward; http://dx.doi.org/10.1007/s00198-018-4745-9; http://www.ncbi.nlm.nih.gov/pubmed/30374598; http://link.springer.com/10.1007/s00198-018-4745-9; https://digitalscholarship.unlv.edu/som_fac_articles/152; https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1151&context=som_fac_articles; https://dx.doi.org/10.1007/s00198-018-4745-9; https://link.springer.com/article/10.1007/s00198-018-4745-9
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