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Rapid screening of marine bacterial symbionts using MALDI-TOF MS

Archives of Microbiology, ISSN: 1432-072X, Vol: 202, Issue: 8, Page: 2329-2336
2020
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Article Description

Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS) is a rapid, cost-effective and high-throughput method for bacteria characterization. However, most previous studies focused on clinical isolates. In this study, we evaluated the use of MALDI-TOF MS as a rapid screening tool for marine bacterial symbionts. A set of 255 isolates from different marine sources (corals, sponge, fish and seawater) was analyzed using cell lysates to obtain a rapid grouping. Cluster analysis of mass spectra and 16S rRNA showed 18 groups, including Vibrio, Bacillus, Pseudovibrio, Alteromonas and Ruegeria. MALDI-TOF distance similarity scores ≥ 60% and ≥ 70% correspond to ≥ 98.7% 16S rRNA gene sequence similarity and ≥ 95% pyrH gene sequence similarity, respectively. MALDI-TOF MS is a useful tool for Vibrio species groups’ identification.

Bibliographic Details

Livia M. R. Vidal; Tainá M. Venas; Aline R. P. Gonçalves; Hannah K. Mattsson; Raphael V. P. Silva; Maria S. Nóbrega; Gustavo P. R. Azevedo; Gizele D. Garcia; Diogo A. Tschoeke; Verônica V. Vieira; Fabiano L. Thompson; Cristiane C. Thompson

Springer Science and Business Media LLC

Immunology and Microbiology; Biochemistry, Genetics and Molecular Biology

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