Targeting ferroptosis by natural products in pathophysiological conditions
Archives of Toxicology, ISSN: 1432-0738, Vol: 98, Issue: 10, Page: 3191-3208
2024
- 2Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Review Description
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different pathophysiological conditions has offered new perspectives on potential therapeutic interventions. Natural products, which are widely recognized for their significance in drug discovery and repurposing, have shown great promise in regulating ferroptosis by targeting various ferroptosis players. In this review, we discuss the regulatory mechanisms of ferroptosis and its implications in different pathological conditions. We dissect the interactions between natural products and ferroptosis in cancer, ischemia/reperfusion, neurodegenerative diseases, acute kidney injury, liver injury, and cardiomyopathy, with an emphasis on the relevance of ferroptosis players to disease targetability.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85198139562&origin=inward; http://dx.doi.org/10.1007/s00204-024-03812-4; http://www.ncbi.nlm.nih.gov/pubmed/38987487; https://link.springer.com/10.1007/s00204-024-03812-4; https://dx.doi.org/10.1007/s00204-024-03812-4; https://link.springer.com/article/10.1007/s00204-024-03812-4
Springer Science and Business Media LLC
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