Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
Psychopharmacology, ISSN: 0033-3158, Vol: 182, Issue: 4, Page: 588-596
2005
- 74Citations
- 48Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations74
- Citation Indexes74
- 74
- CrossRef40
- Captures48
- Readers48
- 48
- Mentions1
- References1
- Wikipedia1
Article Description
Rationale: Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convulsive and antidepressant-like characteristics of these compounds is essential for their potential clinical use. Objective: The present study tests the hypothesis that the rate of delta-opioid agonist administration greatly contributes to the convulsive properties, but not the antidepressant-like effects, of delta-opioid agonists. Materials and methods: The delta-opioid agonist SNC80 (1, 3.2, and 10 mg kg or vehicle) was administered to Sprague-Dawley rats by intravenous infusion over different durations of time (20 s, 20, or 60 min). Convulsions were measured by observation prior to determining antidepressant-like effects in the forced swim test. Results: Slowing the rate of SNC80 administration minimized delta agonist-induced convulsions without altering the effects of SNC80 in the forced swim test. Conclusions: These data suggest that delta agonist-induced antidepressant properties are independent of convulsive effects, and that it may be possible to eliminate the convulsions produced by delta agonists, further promoting their potential clinical utility. © Springer-Verlag 2005.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=26844572244&origin=inward; http://dx.doi.org/10.1007/s00213-005-0138-9; http://www.ncbi.nlm.nih.gov/pubmed/16163520; http://link.springer.com/10.1007/s00213-005-0138-9; http://www.springerlink.com/index/10.1007/s00213-005-0138-9; http://www.springerlink.com/index/pdf/10.1007/s00213-005-0138-9; https://dx.doi.org/10.1007/s00213-005-0138-9; https://link.springer.com/article/10.1007/s00213-005-0138-9
Springer Science and Business Media LLC
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