Impairment of contrast sensitivity in long-term lorazepam users
Psychopharmacology, ISSN: 0033-3158, Vol: 186, Issue: 4, Page: 594-600
2006
- 17Citations
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef10
- Captures26
- Readers26
- 26
Article Description
Rationale: Oculomotor balance and contrast sensitivity are known to be impaired after an intake of a single dose of lorazepam. To the best of our knowledge, these effects have not been explored in long-term users of lorazepam, despite the potential importance of such deficits in everyday life. Objective: We tested the ophthalmological effects and contrast sensitivity for static stimuli in long-term lorazepam users. Materials and methods: There were 15 lorazepam users and 15 sex-, age- and education level-matched control subjects tested, using a simple blind procedure. Results: The ophthalmological effects were scarce, with a discrete exophoria. Visual acuity was preserved. Contrast sensitivity, however, was more markedly impaired, consistent with the effects of an acute dose of lorazepam. The effects were not correlated with anxiety or sedation. Conclusions: The results are discussed in terms of their possible impact on everyday life. As visual acuity does not allow the detection of the impairments that are observed in the present study, it is suggested that a more systematic exploration of contrast sensitivity be carried out in long-term users of benzodiazepines. © Springer-Verlag 2006.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33744960568&origin=inward; http://dx.doi.org/10.1007/s00213-006-0378-3; http://www.ncbi.nlm.nih.gov/pubmed/16586087; http://link.springer.com/10.1007/s00213-006-0378-3; https://dx.doi.org/10.1007/s00213-006-0378-3; https://link.springer.com/article/10.1007/s00213-006-0378-3; http://www.springerlink.com/index/10.1007/s00213-006-0378-3; http://www.springerlink.com/index/pdf/10.1007/s00213-006-0378-3
Springer Science and Business Media LLC
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